Matthew Davids, MD, MMSc, discusses ZUMA-8 results during the 2022 Annual American Society of Hematology Meeting. Hispanics with AML had improved survival compared to non-Hispanic Blacks or non-Hispanic whites in a non-transplant setting. Countries with a lower sociodemographic index are underrepresented in clinical trials of TKIs for the treatment of CML. A whole-genome transcriptome sequencing study of hairy cell leukemia revealed a high degree of genomic complexity. Maintenance therapy with venetoclax plus azacitidine may be a good option after transplant in high-risk acute leukemia. The TKI ponatinib may be the optimal third-line therapy for patients with chronic myeloid leukemia. The VIALE-A trial showed a sustained OS benefit in patients with AML who received venetoclax and azacitidine, Decitabine, venetoclax, and ponatinib was well tolerated in patients with CML in myeloid blast phase or Ph-positive AML. Adherence to oral anticancer agents appeared to be good among adults with chronic myeloid leukemia (CML). The use of venetoclax-containing therapy effectively bridged patients with relapsed or refractory AML. Venetoclax plus HMAs led to higher response rates than non-venetoclax regimens in patients with newly diagnosed AML.