The panel discusses fedratinib for myelofibrosis and whether it's used in the frontline or second line setting. In the fourth segment of the roundtable series, the panel discusses frontline ruxolitinib treatment for myelofibrosis. This roundtable session addresses which patients go directly to transplant, when to observe patients, and more. In the first segment of the roundtable series, the panel discusses how myelofibrosis is diagnosed and assessed. Dr. Naveen Pemmaraju discusses the history of prognostic scoring systems and how they factor into frontline therapy planning.