Symptom-related quality of life is linked with the type of cytoreductive treatment used for MPNs. TP53 and complex karyotype are very high-risk factors in patients with myelofibrosis undergoing HSCT. The combination of ruxolitinib and pegylated IFNα2a showed significant reductions in spleen length. BMS-986158 combined with ruxolitinib or fedratinib reduced spleen volume in patients with myelofibrosis. Selinexor plus ruxolitinib demonstrated promising clinical activity in patients with treatment-naïve myelofibrosis. The combination of interferon and ruxolitinib may be a treatment option for newly diagnosed polycythemia vera. Momelotinib led to an increased likelihood of becoming transfusion-independent compared with danazol in myelofibrosis. Long-term follow-up results of a phase II study of ruxolitinib in patients with MPNs were presented at the 2022 ASH Meeting. New data support the use of ropeginterferon alfa-2b therapy in patients with low-risk or high-risk PV, An analysis of patients with MF found that the combination of navitoclax and ruxolitinib reduced MF-associated splenomegaly. IFNα2 treatment may help reduce the risk of arterial and venous thrombosis in patients with myeloproliferative neoplasms ...