REVEAL is the largest prospective and contemporary cohort of patients with PV in the United States. The OPTIC study evaluated a response-based dose-reduction strategy to optimize the benefit-risk of a TKI in CP-CML. In patients with previously treated CLL and SLL, pirtobrutinib was safe and associated with high rates of response. Farhad Ravandi, MD, and Jeffrey Lancet, MD, squared off on this clinical quandary.